Thoroughly revised, updated, and extended by experts in their fields, and edited by Professors Kevin Taylor and Michael Aulton, Aulton's Pharmaceutics, 7th Edition, comprehensively covers the science and practice of formulation, pharmaceutical manufacturing, and drug delivery. This essential pharmaceutics textbook offers a complete course in one book for students in all years of undergraduate pharmacy and pharmaceutical sciences degrees. It is also an invaluable resource for students undertaking postgraduate studies in the pharmaceutical sciences, practitioners in the pharmaceutical and associated industries, and those working in hospital pharmacy technical services and medicines regulation. It features a clear, readily accessible writing style, extensive illustrations, and numerous tables, figures, and information boxes to assist with the understanding of this complex subject area.- Provides an essential companion to the entire pharmaceutics curriculum from day one until the end of the coursewritten specifically for those new to the design and manufacture of dosage forms- Contains updates from cover to cover, with the addition of new chapters, to reflect advances in formulation and drug delivery science, pharmaceutical manufacturing and medicines regulation- Includes updated information regarding COVID in nanomedicines and biologicals.- Covers relevant pharmaceutical science throughout, including the science of formulation and drug delivery- Reflects current practices and future applications of formulation and drug delivery science to small drug molecules, biotechnology products, and nanomedicines- Includes key points boxes for quick summaries of important information, and more than 400 multiple-choice questions online for self-assessment and review
1. Design of dosage forms
Part 1 Scientific principles of dosage form design
2. Dissolution and solubility
3. Properties of solutions
4. Surfaces and interfaces
5. Disperse systems
6. Rheology
7. Kinetics
Part 2 Particle science and powder technology
8. Solid-state properties
9. Particle size analysis
10. Particle size reduction and size separation
11. Mixing
12. Powder flow
Part 3 Pharmaceutical microbiology and sterilization
13. Fundamentals of microbiology
14. Pharmaceutical applications of microbiological techniques
15. Action of physical and chemical agents on microorganisms
16. Principles of sterilization
17. Sterilization in practice
Part 4 Biopharmaceutical principles of drug delivery
18. Introduction to biopharmaceutics
19. Gastrointestinal tract - physiology and drug absorption
20. Bioavailability - physicochemical, dosage form and formulation factors
21. Assessment of biopharmaceutical properties
22. Dosage regimens
Part 5 Dosage form design and manufacture
23. Pharmaceutical preformulation
24. Solutions
25. Clarification
26. Suspensions
27. Emulsions and creams
28. Ointments, pastes, gels, cutaneous patches and topical sprays
29. Powders, granules and granulation
30. Drying
31. Tablets and compaction
32. Modified-release oral drug delivery
33. Coating of tablets and multiparticulates
34. Continuous manufacturing of tablets
35. Hard capsules
36. Soft capsules
37. Dissolution testing of solid dosage forms
38. Parenteral drug delivery
39. Pulmonary drug delivery
40. Nasal drug delivery
41. Ocular drug delivery
42. Otic drug delivery
43. Topical and transdermal drug delivery
44. Rectal and vaginal drug delivery
45. Preparation and delivery of biopharmaceuticals
46. Pharmaceutical nanotechnology and nanomedicines
47. Radiopharmaceuticals
48. The formulation and manufacture of plant medicines
49. Design and administration of medicines for paediatric and geriatric patients
Part 6 Packaging, stability and pharmaceutical regulation
50. Packaging
51. Chemical stability in dosage forms
52. Microbial contamination, spoilage and preservation of medicines
53. Product stability and stability testing
54. Pharmaceutical quality: the application of pharmaceutics in medicines regulation
Self-assessment questions
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